Philip Nelson

Philip Nelson
Standing Faculty

Professor

he/him/his

Research Areas: Biophysics

(215) 898-7001

DRL 2N8

  • Professor, University of Pennsylvania (1998-)
  • Associate Professor, University of Pennsylvania (1992-1998)
  • Assistant Professor, University of Pennsylvania (1988-1992)
  • Assistant Professor, Boston University (1987-88)

Honors include:

  • Dennis M. Deturck Award for Innovation in Teaching (U Penn) (2018).
  • Emily Gray Award of the Biophysical Society, "for far reaching and significant contributions to the teaching of biophysics, developing innovative educational materials, and fostering an environment exceptionally conducive to education in Biological Physics" (2009).
  • Fellow of the American Physical Society, "For contributions to the understanding of soft biomaterials, quantum fields, and superstrings, using geometrical and topological methods" (2003).
  • Ira Abrams Memorial Award for excellence in undergraduate teaching (U Penn) (2001).
  • National Science Foundation Presidential Young Investigator Award (1988).
  • Alfred P. Sloan Foundation Fellow (1988).
  • Junior Fellow, Harvard University Society of Fellows (1984-87).

 

Education

Ph.D., Harvard University (1984).

Master of Advanced Study, University of Cambridge (1981).

A.B., Princeton University (1980).

Research Interests

I'm currently studying the physics of artificial biomembranes, biopolymers such as DNA, and other "soft" condensed matter systems. There is a great cultural gap between physics, which seeks to understand extremely simple systems, and biology, which is obliged to study the overall behavior of extremely complex systems. I think that one area where simplicity and life intersect is the study of biomembranes and biopolymers, both in isolation and as active elements of cells. Membranes and polymers display the sort of universal behavior amenable to the powerful tools of statistical physics, thus making these systems are a bit more inevitable, less accidental, than more complex architectural elements of life. Nature has made extensive use of these generic properties in constructing useful materials and molecular machines; moreover, artificial analogs of biomaterials are subjects of intense investigation for a wide variety of bioengineering applications. Of course, physicists have been studying membranes and polymers for much of this century. Much physical research on these systems has concerned bulk systems, in thermal equilibrium. But the activities of many molecular actors are obscured when we look at them in bulk; new, single-molecule techniques reveal much that was previously hidden. Also, life processes take place far from equilibrium. So we have been studying mainly experiments involving the manipulation of single molecules of DNA, and dynamical phenomena involving membranes. I have some interest as well in general nonlinear dynamics (including pattern formation), self-assembly, electrostatics at the colloidal level, and the general area of geometrical methods in physics.

Courses Taught

Phys 2280: Physical Models of Biological Systems

Phys 5516: Electromagnetic Phenomena

Selected Publications

Here are my profiles in ResearcherID, ORCID, and Google Scholar. Most of the journal articles are freely available here. I also have some videos.

  • My book: Physical Models of Living Systems Second edition (Chiliagon Science,  2022, ISBN 978-1-7375402-4-3). First edition is also available in Chinese; second Chinese edition is forthcoming.
  • My book: Biological Physics Student Edition: Energy, Information, Life (Chiliagon Science,  2020). First edition is also available in Spanish, Portuguese, and Chinese; second Chinese edition is forthcoming.
  • My book: A Student's Guide to Python for Physical Modeling Second edition (Princeton University Press, 2021, ISBN 9780691223650) (with Jesse M. Kinder). First edition is also available in Korean and Chinese.  Chapter 1 is freely available.
  • My book: From Photon to Neuron: Light, Imaging, Vision (Princeton University Press, 2017, ISBN 9780691175195). Chapter 1 is freely available. Also available in Chinese translation.
  • Effects of Greenhouse Gases on Earth, Venus, and Mars: Beyond the One-Blanket ModelAm. J. Phys. 91:721-730 (2023).
  • Stochastic Simulation to Visualize Gene Expression and Error Correction in Living Cells, 
    The Biophysicist, 1(1), Article 1 (14 pages) (2020) (with K.Y. Chen and D.M. Zuckerman). http://doi.org/10.35459/tbp.2019.000101
  • The Role of Quantum Decoherence in FRET, Biophys. J. 115: 167–172 (2018).
  • Old and New Results About Single-Photon Sensitivity in Human Vision, Physical Biology 20: 025001 (2016).
  • The Syncytial Drosophila Embryo as a Mechanically Excitable Medium PLoS ONE 8: e77216 (2013) (with Timon Idema, Julien O. Dubuis, Louis Kang, M. Lisa Manning, Tom C. Lubensky, and Andrea J. Liu).
  • Transformation of Stimulus Correlations by the Retina, PLoS Computational Biology 9: e1003344 (2013) (with Kristina D. Simmons, Jason S. Prentice, Gasper Tkacik, Jan Homann, Heather K. Yee, Stephanie E. Palmer, and Vijay Balasubramanian).
  • The Role of Microtubule Movement in Bidirectional Organelle Transport, PNAS 105: 10011 (2008) (with I. Kulic, A.E.X. Brown, H. Kim, C. Kural, B. Blehm, P. Selvin, and V. Gelfand).
  • High flexibility of DNA on short length scales probed by atomic force microscopy, Nature Nanotechnology, 1: 137 (2006) (with P. A. Wiggins, T. van der Heijden, F. Moreno-Herrero, A. Spakowitz, R. Phillips, J. Widom, and C. Dekker).
  • Electrostatic Repulsion of Positively Charged Vesicles and Negatively Charged Objects, Science 285: 394 (1999) (with H. Aranda-Espinosa, Y. Chen, N. Dan, T. C. Lubensky, L. Ramos, and D. A. Weitz).
  • Torsional Directed Walks, Entropic Elasticity, and DNA Twist Stiffness, Proc. Natl. Acad. Sci. USA 94: 14418 (1997) (with J. D. Moroz).
  • Global Color is not Always Defined, Phys. Rev. Lett. 50: 943 (1983) (with A. Manohar).

 

 

CV (url)