The figure shows the probability distribution of a single 0.237um-radius polystyrene sphere (cartoon to scale appears at the bottom) inside a vesicle that also contained small spheres (0.042um) with volume fraction 0.30. The white dashed line is the edge of the vesicle, and the colored points indicate the number of times, $N$, the center of the sphere was observed in a bin located at a given point; "hot" colors indicate greater probability. There were 2300 events and the bin size was 65nm. The large sphere was clearly attracted to the vesicle wall, especially where the vesicle was most curved. See Dinsmore et al, below.